Multi-criteria manufacturability indices for ranking high-concentration monoclonal antibody formulations
نویسندگان
چکیده
منابع مشابه
Multi‐criteria manufacturability indices for ranking high‐concentration monoclonal antibody formulations
The need for high-concentration formulations for subcutaneous delivery of therapeutic monoclonal antibodies (mAbs) can present manufacturability challenges for the final ultrafiltration/diafiltration (UF/DF) step. Viscosity levels and the propensity to aggregate are key considerations for high-concentration formulations. This work presents novel frameworks for deriving a set of manufacturabilit...
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ژورنال
عنوان ژورنال: Biotechnology and Bioengineering
سال: 2017
ISSN: 0006-3592
DOI: 10.1002/bit.26329